“How much NMN should I take in a day?” This is a very common question for those just beginning their journey with longevity drugs. For the uninitiated NMN, also known as nicotinamide mononucleotide, which is a direct precursor to NAD+ – an essential enzyme responsible for a myriad of critical cell functions, including DNA repair, metabolism, cell growth and survival.
Why is NMN Important?
NMN is a breakthrough molecule that actually has a lot of research behind it. NMN is important because it boosts our NAD+ levels, which decrease as we age. By supplementing with NMN and increasing our NAD+ levels, we can literally turn back the clock and slow biological aging. NAD+ is required for energy production through metabolism, and helps turn nutrients into energy–without it, life would cease to exist.
NAD+ acts as fuel for the activity of “sirtuins” – which are involved in regulating cellular processes including the aging and death of cells and their resistance to stress. Without sufficient NAD+, these “sirtuins” begin to not work as effectively, especially as our NAD+ levels decline as we age. To quote from David Sinclair’s book Lifespan: “Without sufficient NAD, the sirtuins don’t work efficiently: they can’t remove the acetyl groups from histones, they can’t silence genes, and they can’t extend lifespan.”
By supplementing with NMN, we increase our NAD+ that naturally decline as we age – thus, extending our lifespan.
RELATED READING: David Sinclair’s Complete Longevity Supplement Stack
How Much NMN Should I Take Daily?
So, how much NMN should you take in a day? That is a question researchers have been honing in on recently. One of the most famous studies in mice regarding optimal NMN dosage suggested that the optimal dose for a 137 pound human would be around 500 mgs per day. Using the same math, a 200 pound human would take around 750 mgs per day. Two separate studies – one from researchers at Washington University in St. Louis and another from the University of Tokyo – both have proven that doses as low as 250 mgs of NMN are effective in older humans.
Clinical trials from a research team based in Japan have shown that 500 mg of NMN is easily tolerated orally, so you will likely have minimal side effects from supplementing with NMN. Dr. David Sinclair takes 1000 mg of NMN daily with minimal side effects.
So, how much NMN should you take daily? If we take into consideration multiple studies at different doses and expert opinions, then the average adult should take 500 mgs of NMN per day. The older you are, the more you can take. An adult of the age of 65 can safely take 750 mgs. If you are younger and just start taking it, you could supplement with 250mg daily and still see benefits.
Your age and personal preference will determine your dosage, but you should take at least 250 mgs and no more than 1000 mgs per day.
RELATED READING: Dr. David Sinclair’s NMN & Resveratrol Protocol
Benefits of Supplementing with NMN
Besides the anti-aging benefits, there are additional benefits of supplementing with NMN. Studies have shown the following benefits of supplementing with NMN:
- Increased energy levels: Most people report having more energy while supplementing with NMN. Since NMN increases NAD+ levels, you will likely notice your energy levels are much higher as your cellular energy is higher.
- Improved memory and brain function: Many users report an increase in cognition and memory. This is supported by this study showing increased blood flow and cognition in mice.
- Improved fertility and libido: Users have reported an increase in libido when beginning an NMN supplementation regime. Studies show NMN increases fertility.
How Much NMN Does David Sinclair Take?
Dr. David Sinclair is a legend in the longevity community. He is the co-director of Paul F. Glenn Center for Biology of Aging Research at Harvard University, and is a one of the top longevity scientists on the planet. He is the author of New-York Times Bestseller Lifespan: Why We Age – and Why We Don’t Have To. Dr. Sinclair came to fame when he began appearing on podcasts such as The Joe Rogan Experience.
As one of the pioneers in NMN research, people are often wondering how much NMN Dr. Sinclair takes.
Dr. Sinclair takes 1000mg (1g) of NMN powder in the morning with yogurt. He doesn’t use a specific brand because he uses a very high-quality powder of NMN in his lab. Most NMN products on the market are not pure and contain fillers, so you aren’t getting as much NMN as you think. That’s why it’s best to use a lab-tested company such as Renue By Science for 100% Pure NMN Powder.
How Much Does NMN Cost?
When it comes to NMN supplements, you get what you pay for. There were numerous brands exposed recently on Amazon for containing little to no amounts of the NMN they claimed. Of the 21 brands analyzed, only three contained their claimed amounts, with an appalling 14 brands containing less than 1% of the NMN claimed. So if you are buying a cheaper NMN supplement, you’re better off spending your money on a brand that shows their lab tests such as Renue By Science.
Where to Buy
With its rise in popularity, multiple companies have begun to sell NMN products. We have tested multiple different brands and products, and you should not try taking a chance to save money by ordering one of the cheaper ones off of Amazon. The most reputable brand when it comes to longevity supplements is Renue By Science. The products are third-party tested, cGMP certified, and produced in an FDA approved facility. For NMN supplementation, we recommend the powder form. Renue By Sciences Pure NMN Powder is 100 grams of Pure Crystalline NMN Powder. If you take 500mg a day, you are spending less than 50 cents a day! You can pick it up here on their website.
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