7 Best NMN Supplements in 2025 – A Biohacker’s Review

As the lead writer over here at BrainFlow and someone who’s been deep in the biohacking trenches for over a decade, I’ve personally tested dozens of NMN supplements. When I started my journey with NAD+ precursors back in 2019, the market was still in its infancy. Fast forward to 2025, and we’re now seeing sophisticated formulations backed by actual clinical data – a game-changer for those of us serious about longevity.

I’ve spent the last 3 months rigorously testing the latest NMN supplements, measuring my biomarkers and tracking subjective improvements in energy, recovery, and cognitive function. This isn’t just about reading labels – it’s about finding what actually works in real human biology (specifically, mine).

Our Top 7 NMN Supplements for 2025

• Best Overall: Renue By Science Liposomal NMN Capsules
• Best High-Dose Capsule: ProHealth Longevity NMN Pro 1000
• Best Budget Option: Renue By Science NMN Pure Powder
• Best Combination Formula: Wonderfeel Youngr NMN
• Best NMN/Resveratrol Combo: Omre NMN + Trans-Resveratrol
• Best for Metabolic Health: Lifeforce Peak NMN
• Best Nasal Delivery: Renue By Science Liposomal NAD+ Complex Nasal Spray

Why NMN Matters for Longevity Enthusiasts

Before diving into my top picks, let’s quickly recap why NMN (Nicotinamide Mononucleotide) has become the gold standard for NAD+ boosting.

As a direct precursor to NAD+ (nicotinamide adenine dinucleotide), NMN replenishes cellular levels that naturally decline with age.[1] NAD+ serves as a critical coenzyme for hundreds of metabolic reactions – it’s essentially the cellular currency that powers everything from DNA repair to energy production.[2]

What makes NMN particularly valuable is its ability to cross cell membranes via specific transporters, directly elevating NAD+ more efficiently than earlier precursors like nicotinamide riboside (NR).[3] For biohackers seeking measurable improvements in mitochondrial health, metabolic flexibility, and cellular resilience, quality NMN has become non-negotiable.

Now, let’s get into what you’re here for – the supplements that actually deliver results, backed by both science and personal experience.

How We Selected and Tested These NMN Supplements

I’ll be honest – reviewing supplements isn’t as straightforward as comparing smartphones where you can run benchmark tests and get clear numbers. After testing dozens of NMN products over the years (and wasting plenty of money on overhyped duds), I’ve developed a real-world approach to separating the exceptional from the mediocre. Here’s what actually mattered in my evaluation process:

Verified Purity & Manufacturing Standards

The supplement industry can be frustratingly unregulated, which is why I immediately eliminated any product without third-party testing documentation. Each supplement in this guide maintains minimum 98% purity with accessible Certificates of Analysis that I personally reviewed. I’ve seen too many companies cutting corners with manufacturing, so I prioritized brands using pharmaceutical-grade NMN produced in FDA-registered, cGMP-compliant facilities. You’d be shocked how many popular brands failed this basic requirement.

Absorption Technology That Actually Works

An uncomfortable truth about NMN supplementation: even the purest powder is worthless if it degrades before reaching your cells. I learned this lesson the expensive way back in 2019 with my first NMN purchase. For this guide, supplements using scientifically-backed delivery methods (liposomal encapsulation, sublingual formulations, enteric coatings, or nasal sprays) generally outperformed standard capsules in my testing. The difference wasn’t subtle – especially with the liposomal and nasal delivery systems that consistently produced noticeable effects within 20-30 minutes.

Formula Intelligence & Synergistic Ingredients

The supplement market is flooded with “kitchen sink” formulas throwing together trendy ingredients without scientific rationale. I evaluated each product’s complementary ingredients based on research-backed synergy rather than marketing buzz. Additions like trans-resveratrol earned points for proven sirtuin activation alongside NMN, while proprietary blends hiding actual dosages behind “proprietary blends” were immediately suspect. Some of the most impressive performers combined NMN with targeted compounds that address complementary longevity pathways.

Company Reputation & Transparency

After years in the biohacking community, you develop a sense for which companies are in it for the long haul versus those chasing quick profits. I heavily favored brands with established track records in the longevity space, accessible scientific teams, and transparent communication about sourcing and manufacturing. I personally reached out to each company’s customer service with technical questions about their NMN stability testing and manufacturing processes – the variation in knowledge and helpfulness was truly eye-opening and significantly influenced these rankings.

Real Value (Not Just Lowest Price)

I’ve learned the hard way that “cheap” NMN usually means wasted money. For this guide, value was calculated beyond simple price-per-gram comparisons. Some premium-priced products earned high rankings by delivering superior bioavailability that justified their cost – effectively providing more functional NMN per dollar despite the higher price tag. Budget options were judged on their quality-to-price ratio rather than merely being the cheapest available. The recommendations reflect supplements delivering the best real-world results for their respective price points.

Authenticated User Experiences

While my personal testing formed the foundation of these reviews, I’ve learned that individual biochemistry varies tremendously. To broaden the perspective, I integrated feedback from hundreds of verified purchasers across review platforms and insights from fellow biohackers in the BrainFlow community who’ve used these products for 6+ months. This helped identify consistent patterns in effectiveness, side effects, and long-term satisfaction beyond my own experience.

The final rankings reflect supplements that consistently delivered real results across multiple users, maintained impeccable quality standards, and provided genuine value regardless of price point. I personally use products from this list daily and regularly recommend them to friends and family – which is perhaps the most honest endorsement I can offer.

Comparison Table: Top 7 NMN Supplements for 2025

Product	NMN Amount	Formula Type	Special Features	Price/Value	Best For
Renue By Science Liposomal NMN	250mg per capsule	Liposomal capsule	Enhanced bioavailability, 99% pure, 4× lab tested	$1.16/day (500mg dose)	Best overall; superior absorption
ProHealth NMN Pro 1000	1000mg	Enteric capsule	Acid-resistant delivery, Uthever® NMN, clinical testing	$3.83 per 1000mg ($115/30 caps)	Maximum dosage in one capsule
Renue By Science Pure NMN	Flexible (250mg-1g)	Powder	Sublingual option, 99% pure, 4× lab tested	$0.16 per 250mg dose ($64.95/100g)	Best budget value
Wonderfeel Youngr	900mg	Multi-ingredient capsule	With resveratrol, ergothioneine, olive extract, vit D3	$2.93 per serving ($88/30 servings)	Comprehensive longevity stack
Omre NMN + Resveratrol	500mg	Dual-action capsule	With 500mg resveratrol & BioPerine®	$2.00 per serving ($59.97/30 servings)	Sirtuin activation plus NAD+ boosting
Lifeforce Peak NMN	375mg	Metabolic formula	With berberine, mulberry extract, spermidine & lithium	~$3.33 per serving (~$100/30 servings)	Blood sugar management & longevity
Renue By Science NMN Nasal Spray	2.5mg per spray	Nasal spray	Direct absorption, rapid onset, potential brain-targeting	~$4.00/day (16 sprays)	Fast-acting cognitive benefits

1. Renue By Science Liposomal NMN Capsules – Best Overall

Why It’s My #1 Pick: After extensive testing across dozens of NMN supplements, Renue’s Liposomal NMN Capsules consistently delivered the most noticeable benefits with the highest bioavailability. These capsules utilize advanced liposomal technology that encapsulates the NMN molecules within phospholipid bilayers – essentially mimicking the body’s own cell membranes to dramatically improve absorption and cellular delivery.

The liposomal delivery system provides significant advantages over traditional capsules by protecting the NMN from degradation in the digestive tract and facilitating direct cellular uptake.[4] Each capsule delivers 250mg of pharmaceutical-grade NMN (>99% pure) wrapped in non-GMO sunflower lecithin liposomes.

What truly impressed me during my 60-day testing period was the consistent energy enhancement and notable improvements in recovery metrics compared to standard NMN formulations. My continuous glucose monitor showed improved metabolic responses within just 10 days, and my sleep tracker recorded measurably deeper sleep phases by week three.

Renue By Science maintains exceptional quality standards with four rounds of third-party testing for every batch, with published Certificates of Analysis verifying purity, potency, and absence of contaminants. Their manufacturing follows cGMP standards in FDA-registered facilities – something surprisingly uncommon in the supplement industry.

Price: $69.95 for 60 capsules (30-day supply at 2 capsules daily). That’s approximately $1.16 per day for 500mg daily dosing – an excellent value considering the advanced delivery technology. BrainFlow readers get 10% off with code “brainflow” at checkout!

Customer Experience: The biohacking community consistently rates these capsules 4.7/5 stars across platforms. The company’s responsive customer support and satisfaction guarantee further enhance the buying experience.

The Bottom Line: For those seeking maximum NAD+ enhancement with convenient once-daily dosing, Renue’s Liposomal NMN Capsules offer the perfect combination of superior bioavailability, exceptional purity, and scientifically advanced delivery. They earn my top recommendation for serious biohackers and longevity enthusiasts.

2. ProHealth Longevity NMN Pro 1000 – Best High-Dose Capsule

When convenience matters or when traveling, I reach for ProHealth Longevity NMN Pro 1000 enteric-coated capsules. The standout feature here is the acid-resistant coating that protects NMN from degradation in the stomach and delivers it intact to the small intestine, where dedicated transporters can efficiently absorb it.

ProHealth uses Uthever® NMN (>99% pure) and provides detailed COAs for every batch. What impressed me was finding actual published human clinical data showing significant NAD+ increases with their specific product. Each capsule delivers a full gram (1000mg) of NMN – perfect for those following protocols similar to Dr. David Sinclair’s regimen.

The enteric coating makes a noticeable difference. When I switched from standard capsules to these, I experienced stronger effects despite taking the same dose. The company claims this is because standard capsules may lose up to 50% of NMN to stomach acid degradation – and based on my personal response, I believe it.

Price: $115 for 30 capsules (30-day supply at 1 capsule daily). That’s $3.83 per gram – not the cheapest option, but reasonable considering the specialized delivery technology and high-grade Uthever® NMN.

The Bottom Line: These capsules earn second place for their convenience combined with advanced delivery technology. They’re my go-to when traveling or when I need plug-and-play simplicity without sacrificing quality.

3. Renue By Science NMN Powder – Best Budget Option

Why It’s a Smart Value: For cost-conscious biohackers who don’t mind a slightly more hands-on approach, Renue by Science’s bulk NMN powder offers unbeatable value. The flexibility in dosing and sublingual administration option makes this a fantastic choice for those who want to maximize their NAD+ investment.

What sets this powder apart is the option for sublingual administration – bypassing first-pass metabolism in the liver and allowing direct absorption through the oral mucosa.[5] While not as convenient as the liposomal capsules, the sublingual method provides excellent bioavailability at a fraction of the cost.

Renue’s NMN undergoes the same rigorous four rounds of analysis as their capsule products, with full Certificates of Analysis verifying >99% purity. The powder dissolves cleanly with minimal taste, making it easy to hold under the tongue for 3-5 minutes before swallowing.

For those tracking precise protocols, you can measure exact doses with an inexpensive milligram scale. Many users start with 250mg per day and gradually increase as needed – the bulk format allows for this personalized approach.

Price: $64.95 for 100g (or just $58.45 using code ‘brainflow’ at checkout) – that’s about $0.16 per 250mg dose, or $0.65 per gram. Even at higher doses of 1g daily, that’s under $20/month – dramatically cheaper than any encapsulated option. BrainFlow readers get 10% off with code “brainflow” at checkout!

The Bottom Line: If budget optimization is important and you don’t mind the sublingual administration process, Renue’s powder provides exceptional value without compromising quality. The combination of third-party testing, good bioavailability, and unmatched price-per-dose makes this my top recommendation for cost-conscious biohackers.

4. Wonderfeel Youngr NMN – Best Combination Formula

Youngr stands out for its comprehensive approach to longevity. Each 2-capsule serving delivers 900mg of high-purity NMN alongside 100mg trans-resveratrol, 50mg olive fruit extract, 4mg ergothioneine, and 20μg vitamin D3. This “stack-in-a-bottle” approach addresses multiple longevity pathways simultaneously.

I was initially skeptical of combination products (I prefer building custom stacks), but after a 30-day trial, I was genuinely impressed. The synergistic effects of NMN with resveratrol (a sirtuin activator)[6] and ergothioneine (a powerful mitochondrial protector)[7] created noticeable improvements in sustained energy and recovery beyond what I experienced with NMN alone.

Developed with Harvard MD Dr. Andrew Salzman, Youngr uses pharmaceutical-grade NMN (>99% pure) and publishes third-party test results. The biggest downside is the standard (non-enteric) capsules, which may reduce bioavailability compared to enteric options or sublingual methods.

Price: $88 for a 30-day supply, or about $2.93 per serving (900mg NMN plus complementary ingredients). Subscribers pay around $73, bringing it to $2.43 per day.

The Bottom Line: If you want a science-backed “all-in-one” approach rather than buying multiple supplements separately, Wonderfeel Youngr offers excellent value and convenience. It’s my recommendation for biohacking beginners or those who want simplified supplementation without sacrificing quality.

5. Omre NMN + Trans-Resveratrol – Best NMN/Resveratrol Combo

Omre targets the popular Sinclair-inspired stack of NMN + resveratrol, delivering 500mg of each per serving. What makes their formula stand out is the addition of BioPerine® (black pepper extract) to enhance the notoriously poor bioavailability of resveratrol.

The product uses premium Uthever® NMN and micronized trans-resveratrol for better absorption. In my testing, I found Omre’s combination provided similar benefits to taking separate NMN and resveratrol supplements but with greater convenience and likely better resveratrol utilization due to the BioPerine®.[8]

Transparency is exceptional here – the company shares detailed test results showing exact potency and purity, and they use vegetarian capsules free from unnecessary fillers. One tip from my experience: take this with a small amount of fat (I use MCT oil) to further improve resveratrol absorption.[9]

Price: $59.97 for a 30-day supply, or about $2.00 per serving (500mg NMN + 500mg resveratrol). Subscribers save additional money.

The Bottom Line: For those specifically wanting to implement the Sinclair protocol of NMN + resveratrol without managing multiple supplements, Omre provides a high-quality, well-absorbed option at a reasonable price point. It’s my recommendation for those specifically targeting sirtuin activation alongside NAD+ enhancement.

6. Lifeforce Peak NMN – Best for Metabolic Health

Co-founded by Tony Robbins and Peter Diamandis, Lifeforce created a unique metabolic health formula combining 375mg NMN with 660mg berberine HCl, 200mg white mulberry extract (Reducose®), 5.7mg spermidine, and 450mcg lithium orotate.

What makes this formulation stand out is its comprehensive approach to metabolic optimization. Berberine functions similarly to metformin for glucose management (some call it “nature’s Ozempic”)[10], mulberry extract blunts sugar spikes[11], spermidine promotes autophagy[12], and low-dose lithium supports neural health.

During my 45-day trial, I noticed Peak NMN had the strongest immediate effects on glucose control of any supplement in this lineup. My continuous glucose monitor showed dramatically improved post-meal responses – likely from the berberine and Reducose®. Mental clarity also improved, possibly from the NAD+/lithium combination.

Price: Approximately $99-$105 for a 30-day supply ($3.30-$3.50 per day). While this is premium pricing, you’re getting five evidence-based compounds that would cost significantly more purchased separately.

The Bottom Line: For those specifically targeting metabolic health alongside NAD+ enhancement, Lifeforce Peak NMN offers a science-backed, comprehensive approach. I recommend it particularly for those over 40 or anyone dealing with blood sugar management concerns alongside their longevity goals.

7. Renue By Science Liposomal NAD+ Complex Nasal Spray – Best Multi-Compound Nasal Delivery

Why It’s Revolutionary: Renue’s NAD+ Complex Nasal Spray represents the pinnacle of NAD+ enhancement technology, utilizing a comprehensive liposomal complex that delivers multiple NAD+ boosters through a single application. Each precision spray contains a synergistic blend of 10mg NMN, 5mg NAD+, 3mg NR, and 3mg trigonelline, all encapsulated in advanced liposomes for maximum bioavailability and cellular uptake.

What makes this formula particularly innovative is the multi-pathway approach to NAD+ enhancement. By combining direct NAD+ with three distinct precursors (NMN, NR, and trigonelline – a recently discovered NAD+ booster derived from coffee), the spray targets multiple metabolic pathways simultaneously. The nasal delivery method brilliantly bypasses both digestive degradation and first-pass liver metabolism, allowing these compounds to absorb directly through the nasal mucosa for rapid entry into the bloodstream and enhanced brain bioavailability.

During my 30-day testing period, I was genuinely impressed by the rapid onset of effects compared to oral supplements. Within just 15-20 minutes of administration, I experienced a noticeable increase in mental clarity, focus, and cognitive processing speed – significantly faster than the 45-60 minutes typically required with capsules or even sublingual administration methods. The inclusion of trigonelline was particularly intriguing, as this compound has been shown to not only boost NAD+ levels but also support glucose metabolism and neuronal health.[13]

The liposomal delivery system deserves special mention. The phospholipid bilayers encapsulating the active compounds mirror the body’s own cell membranes, facilitating direct cellular delivery while protecting the delicate NAD+ molecules from degradation. This technology dramatically improves bioavailability compared to standard formulations.

What truly distinguished this product during my testing was the sustained cognitive enhancement throughout the day. Unlike the temporary “boost” often experienced with stimulants, the effects built progressively with consistent use. By week three, I noticed a pretty significant increase in cognitive abilities and memory.

Price: $69.95 per bottle with approximately 300mg of active compounds total. At the recommended dosage of 3-4 sprays twice daily, each bottle lasts about 10-14 days, making the monthly cost approximately $140-$210. While this represents a premium price point compared to oral supplements, the enhanced bioavailability, rapid onset, and comprehensive formula make it worthwhile for serious biohackers. BrainFlow readers get 10% off with code “brainflow” at checkout!

Customer Experience: The biohacking community has responded enthusiastically to this innovative delivery method, with an average rating of 4.8/5 stars across review platforms. Many users specifically highlight the noticeable cognitive benefits and the convenience factor compared to managing multiple supplements separately.

The Bottom Line: For those seeking the most comprehensive approach to NAD+ enhancement with maximum bioavailability, Renue’s Liposomal NAD+ Complex Nasal Spray represents the cutting edge of current supplementation technology. The synergistic combination of NMN, NAD+, NR, and trigonelline in a liposomal delivery system makes this particularly valuable for biohackers focused on cognitive optimization and neurological health alongside general longevity benefits. It’s my top recommendation for those who want to experience the most direct and immediate effects from their NAD+ supplementation protocol.

My Personal NMN Protocol and Recommendations

After years of self-experimentation and keeping up with the research, here’s what I currently do:

Daily Protocol:

• 2 Renue By Science Liposomal NMN Capsules in the morning with breakfast
• 4 sprays of Renue By Science NMN Nasal Spray mid-afternoon for an immediate cognitive boost

When Traveling:

• 1 ProHealth NMN Pro 1000 capsule daily (convenient single capsule)
• Renue By Science NMN Nasal Spray (perfect travel-friendly option that doesn’t count as a liquid in carry-on luggage)

Budget Option:

• For those on a tight budget, 500mg Renue By Science NMN powder sublingually twice daily offers exceptional value

Cycling: Every 3-4 months, I take a 5-7 day break from NMN supplementation. Some researchers suggest periodic breaks may upregulate NAD+ production pathways naturally. I’ve noticed I actually feel a distinct energy boost when restarting after these short breaks.

For Beginners: Start with 250mg daily for 2 weeks, then increase to 500mg if well-tolerated. The “more is better” approach isn’t always necessary – find your minimum effective dose.

Timing: Taking NMN earlier in the day seems to work best for most people, as NAD+ is involved in circadian regulation. I avoid taking it within 4 hours of bedtime as it occasionally causes sleep disturbances for me when taken too late.

Stacking: Consider pairing NMN with a methylation supporter like TMG (trimethylglycine) if taking higher doses long-term. NAD+ metabolism can increase methyl group consumption, and supporting this pathway is prudent.

Final Thoughts on NMN Supplementation in 2025

The NMN market has matured significantly since I first started covering it at BrainFlow. What was once a niche supplement with questionable sourcing has evolved into a scientifically-validated category with legitimate players and real quality control.

Remember that NMN is just one piece of the longevity puzzle. While boosting NAD+ addresses a fundamental aspect of aging, it works best as part of a comprehensive approach including proper sleep, nutrition, stress management, and physical activity.

For most people serious about longevity, I recommend starting with Renue By Science’s Liposomal NMN Capsules for the optimal combination of quality, bioavailability, and convenience. For those focused on cognitive performance or looking for faster-acting benefits, their NMN Nasal Spray is worth adding to your regimen. And if budget is a primary concern, their Pure NMN Powder provides exceptional value while maintaining quality. Don’t forget to use code “brainflow” at checkout for 10% off your order!

If cost is no object and you want the absolute best combination of ingredients, Wonderfeel Youngr provides an exceptional all-in-one formula. And for those specifically targeting metabolic health, Lifeforce Peak NMN offers unique synergistic benefits.

Have you tried any of these NMN supplements? I’d love to hear about your experiences in the comments below. As always, I’ll be updating this guide as new research emerges and products evolve.

Stay optimized.

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