Joe Rogan is a notorious biohacker, with an insanely famous supplement stack. Most recently, Joe hosted Harvard professor of genetics and longevity expert Dr. David Sinclair on his podcast.
During his work at Harvard, Dr. Sinclair has been able to discover two compounds that have been shown to increase longevity in clinical trials – NMN & Resveratrol.
Joe being Joe, he started the same anti-aging regime that Dr. Sinclair follows.
You can check it out below.
Joe Rogan’s Anti-Aging Supplement Stack
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Benefits of NMN
NMN – also known as nicotinamide mononucleotide – is the hottest thing to hit the longevity scene, as it has been clinically proven in studies to extend lifespan. It does so by converting into a molecule called NAD+, which is described below. Here’s what this study had to say about NMN:
“Across the kingdom of life, an increase in intracellular levels of NAD+ triggers shifts that enhance survival, including boosting energy production and upregulating cellular repair.5 In fact, the slow, ineluctable process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”6 Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.7,8
By middle age, our NAD+ levels have plummeted to half that of our youth.9 Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.10,11 NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).12,13 A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, posits NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.6
Taken orally, NMN is rapidly absorbed and converted to NAD+.14 In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+.15 Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.”
We do not recommend buying NMN off Amazon or trying to buy the cheapest NMN supplement. In fact, there was a study that tested 21 NMN supplements off Amazon and found that an astounding 14 of them contained LESS THAN 1% of the NMN claimed on the bottle. This is why we recommend Renue by Science, as they are pioneers in the industry and contain 100% of the ingredients claimed on the label.
RELATED READING: Dr. David Sinclair’s Anti-Aging Supplement Stack
Benefits of Resveratrol
You may have heard that drinking a glass of wine per day has been known to increase lifespan. This is due to resveratrol. Resveratrol – made famous by Dr. David Sinclair – is part of a group of compounds known as polyphenols. Resveratrol is an antioxidant that protects the body from damage that can put you at a higher risk of age-related diseases such as heart disease, diabetes, heart disease, and even cancer.
Dr. Sinclair believes that resveratrol works hand-in-hand with NMN. Resveratrol is needed to activate sirtuins (a protein that protects our DNA and epigenome), while NMN is needed to fuel the sirtuins. Dr. Sinclair recommends mixing 0.5g of resveratrol with 1g of NMN in the morning with yogurt.
RELATED READING: Renue by Science NMN Review: My 90-Day Journey
Here is an excerpt from Boston Mag regarding Sinclair’s discovery of resveratrol’s longevity properties: “True to form, he got to work, harder and faster than anyone else, Imai says. He screened some 20,000 substances until, one day, his collaborator called to say that he’d gotten a hit: resveratrol, a molecule found in red wine that has long been suspected to play a role in human health. Sinclair couldn’t believe what he was hearing and knew others wouldn’t, either. So he set out to disprove the finding right on his dining room table, where he lined up a series of petri dishes filled with yeast that had been fed different substances. When he discovered that the dish with yeast that lived 50 percent longer had been fed resveratrol, he cried out to his wife, “I think we have found something important here.”
Like NMN, resveratrol is one of those supplements you should avoid buying on Amazon and only buy from a trusted source. We once again recommend Renue by Science for resveratrol powder.
RELATED READING: Joe Rogan’s Insane Supplement Stack
