Top 5 Best Brain Supplements To Improve Focus – Updated 2019

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As our world gets more competitive and intense, many people are turning to natural brain supplements to help them get a mental edge to improve focus, memory, and mood.

Brain supplements that boost focus will have a multitude of different types of brain-boosting vitamins and brain-enhancing amino acids in them. These vitamins and amino acids work together as a catalyst for increasing neurotransmitter activity, thus improving concentration span and memory recall.

Many brain supplements for improving focus contain more than one focus-boosting ingredient, making it difficult to tell which ones actually work, and which ones don’t. This article dives into existing research, and ranks the Top 5 Brain Supplements to improve focus, memory, concentration, and everything else. If you’re looking to get a mental edge, look no further.

#1 Alpha Brain

Alpha Brain by Onnit is at the top of our list of best brain supplements to improve focus, simply because it is the best brain supplement on the market. Alpha Brain has unwavering positive reviews, and works the first time you take it. According to the Onnit website, “Alpha Brain may help you remember names and places, focus on complex tasks, and improve your mental speed in response to stimuli. Whether it is a work project, a social gathering, or an athletic performance, taking Alpha BRAIN is like another gear for your brain.”

Alpha Brain is one of the few brain supplements that is actually backed by clinical studies. One clinical study on Alpha Brain was published in Journal of Human Psychopharmacology: Clinical and Experimental concluded that Alpha Brain was shown to increase focus, memory, and executive function. The study was double blind, randomized, placebo-controlled, and conducted by the Boston Center for Memory. It says a lot when a brain supplement is put through a clinical trial that not only proves it to work, but is also published in a reputable journal.

So, what’s in Alpha Brain you ask that makes it so special?

Onnit Flow Blend, 650 mg

  • L-Tyrosine – a precursor to many major neurotransmitters that improves alertness, attention and focus – along with regulating mood and decreasing stress.
  • L-Theanine – an amino acid rarely found in nature that increases levels of neurotransmitters such as dopamine, serotonin, and GABA. Induces a calm, relaxed flow state.
  • Oat (Straw) Extract – alleviates neurological stress and exhaustion, and studies have shown it has a positive impact on cognitive performance.
  • Phosphatidylserine – a phospholipid that protects brain cells, while also carrying messages between them. Plays a key role in keeping your memory and focus sharp. Studies have shown levels decrease as we age, and supplementing in the elderly improves memory. 

Onnit Focus Blend

  • Alpha-GPC – a safe, highly studied source of choline. It is a powerful memory enhancer that also improves focus, increases muscular strength, and stimulates the release of growth hormones.
  • Bacopa Extract – a popular herb in Ayurvedic medicine that has been used for years due to it’s positive effect on brain function. Regulates stress, improves memory, and helps repair damaged neurons.
  • Huperzine-A – a popular ingredient in brain supplements. Supports memory and cognitive performance, increases REM sleep, and acts as a neuroprotective agent. Also improves levels of the neurotransmitter acetylcholine.

Onnit Fuel Blend, 65 mg

  • L-Leucine – essential amino acid that slows muscle deterioration, aids in muscle growth and energy, and improves general overall health
  • Vinpocetine – increases oxygen and blood flow to the brain, which in turn improves brain metabolism, improves focus and memory, and overall cognitive health.
  • Pterostilbene – a potent antioxidant that protects against memory loss, high cholesterol, and high-blood pressure. Also has anti-aging properties and fights against oxidative stress.

Additional Alpha Brain Ingredients

  • Vitamin B6 – a water-soluble vitamin that plays a key role in macro-nutrient metabolism and the creation of red blood cells and neurotransmitters. Your body cannot produce B6 on it’s own, so it must be consumed through food and supplements.
  • Cat’s Claw Extract – a rain forest “super herb” found in the Amazon rain forest that has been shown to boost immune system, fight viral infections and inflammation. Eliminates free radicals known to cause cellular damage and even repairs damaged DNA.

The best deal for Alpha Brain is through the Onnit website. Use code ‘brainflow‘ for 10% off!

You can also pick up Alpha Brain on Amazon.

#2 Neuro-Peak


Neuro-Peak by Zhou Nutrition comes in at number one on our list of best brain supplements to improve focus. There was great care in combining just the right amount of each ingredient into a premium formula designed to support memory, focus and clarity. This product is a best-seller, with over 5,622 reviews on Amazon. Neuro-Peak is a “Nootropic”, meaning that it was formulated to help support memory and cognition. The unique combination in this blend is crafted to help support oxygen and circulation in the brain, brain cells and neurons. This product is loaded with scientifically-backed ingredients such as:

DMAE (Dimethylaminoethanol)
DMAE is thought to promote the production of the neurotransmitter, acetylcholine.

BACOPA MONNIERI
Believed to provide support for the protein network in the brain where signals are transmitted from one neuron to another. Bacosides are natural chemical compounds found in Bacopin. These compunds are believed to support Kinase, the protein in the body that replaces worn-out neurons with new ones.

PHOSPHATIDYLSERINE
A phospholipid present in the structure of cell membranes. Research conducted in Italy during the 1980’s investigated the potential for phosphatidylserine to help support memory, learning and nerve cell health in certain areas of the brain.

RHODIOLA ROSEA EXTRACT
A Russian herb long used for optimal performance. Popular with athletes for its potential to ‘re-energize’. Researched for its ability to provide support for healthy levels of serotonin and dopamine, so the mind can stay focused on the tasks at hand.

GINKGO BILOBA EXTRACT
Believed to support healthy brain function.

#3 NeuroIGNITE


This fast-acting brain booster formula comes in at #2 on our list. This amazing supplement was carefully formulated to help enhance your mental performance, promote a positive mood, increase natural energy and ignite your mind’s full potential. This product is scientifically backed, and allows you to stay alert and focused using safe and natural ingredients. This product is a go-to among loads of people, as it does not provide the jittery crash that caffeine does. The ingredients in NeuroIGNITE support healthy activity, and help to enhance your mood so you can focus on what’s important. NeuroIGNITE is packed with the following ingredients:

St. Johns Wort
An uplifting herb clinically studied to support an overall healthy mood and outlook.*

Bacopa Monnieri
Supports cognitive function including memory and learning capacity, as well as the body’s response to stress. All of these supplements include this ingredient.

Phosphatidylserine
An important compound of all cells in the body, but it is highly concentrated in the walls of brain cells where it is known to promote the function of neurotransmitters responsible for vital cell-to cell communication.

Acetyl-L-Carnitine
A unique form of the amino acid L-carnitine, Acetyl-L-carnitine, has been studied and shown to help maintain healthy brain function.*

Ginkgo Biloba Extract
Supports mental alertness, concentration and circulation to the brain.

Huperzine A
A plant-derived compound known to help enhance learning and alertness

#4 NuClarity

Boost your energy, focus, and motivation with NuClarity. Feel renewed mental energy using the 7 most effective and purified clinically proven ingredients found in nature, including Ginkgo Biloba, Phosphatidylserine, Rhodiola Rosea, and more. This formula was designed to increase circulation in the brain and enhance cell-to-cell communication. This natural nootropoic contains Alpha-GPC which is a powerful brain enhancer that works great by itself. Like every other supplement on this list, it is packed with high-quality ingredients. Here are the ingredients that are loaded into NuClarity:

Bacopa Monnieri
Ancient herb used in traditional medicine for centuries as a memory booster. Supports the efficiency of neurotransmission, enhances mental focus & promotes brain tissue regeneration.

Alpha-GPC
Most bioavailable cholinergic compound for nootropics and brain supplements. Crucial in enhancing acetylcholine synthesis. Improves ability to think and concentrate & provides neuroprotection to slow age-related cognitive decline.

Acetyl-L-Carnitine
Helps convert choline to acetylcholine. Improves communication between neurons, reduces physical & mental fatigue, cures brain fog & increases cerebral blood flow.

Phosphatidylserine
Vital phospholipid for enhancing cell-to-cell communication in the brain. Beneficial for ADHD, memory formation & stress reduction. Improves attention span & processing speed & accuracy.

Ginkgo Biloba
All natural herb that shields an aging brain from oxidative damage while supporting memory retention & information recall. Stabilizes mood, improves circulation in the brain & improves sleep quality.

Rhodiola Rosea
Scandinavian herbal supplement known for promoting physical & cognitive vitality. Reduces fatigue & exhaustion in prolonged stressful situations. Boosts processing accuracy & subjective well-being.

Huperzine A
Cognitive enhancing herb that prevents memory loss & supports learning capabilities, neuroprotection & acetylcholine synthesis. Promotes mental clarity & improves concentration.

#5 Brain Boost


Brain Boost by Arazo Nutrition is an all-natural Nootropic, formulated to help support memory and cognition. The perfect blend of ingredients will increase oxygen and circulation in the brain, brain cells and neurons. You will remember more easily and think better without brain fog or stress. Brain Boost comes in with over 41 ingredients packed into a premium formula designed to boost your focus, memory, concentration and clarity. Perfect for college students, busy moms, or an overloaded professional. This product is a best-seller on Amazon, with almost 1,000 4-5 star reviews! Here are the top ingredients in Brain Boost:

Dimethylethanolamine
Elevates mood, improves learning, heightens intelligence by promoting production of the neurotransmitter, acetylcholine

PHOSPHATIDYLSERINE 20%
Supports retention of information, learning and nerve cell health

L-GLUTAMINE
Reduces stress, increases mental alertness

CHOLINE
Important macronutrient to improve cognitive functioning

INOSITOL
A valuable natural remedy to calm anxiety and panic attacks

N-ACETYL L-TYROSENE
Enhances mood during stress

HUPERZINE-A
Supports nerve health, memory, learning and alertness

GRAPE SEED EXTRACT
Boosts cerebral oxygen flow

GRAPE AND GRAPEFRUIT SEED EXTRACT
Contains the polyphenols Pterostilbene and Resveratrol for cognitive enhancement

GABA
Supports mood, sleep, focus

BACOPA MONNIERI LEAF
Helpful for memory and combating stress

BILBERRY FRUIT EXTRACT
Improves blood supply to the brain for better concentration

OLIVE LEAF
Improves cognitive function

CINNAMON BARK EXTRACT
Effective in boosting memory

LICORICE ROOT EXTRACT, BOROM, DHA and VANADYL SULFATE…. and more!